Developing transmissible vaccines for animal infections

Author
Affiliation

David Simons

The Royal Veterinary College

Published

February 28, 2025

Coordinating the development of self-disseminating vaccines for spillover prevention - workshop

In March 2023 I was an invited participant to a workshop organised by Prof. Scott Nuismer and Prof. Daniel Striecker. The workshop was designed to bring together an interdisciplinary group of researchers and practitioners to discuss the development of self-disseminating vaccines that could dramatically reduce or eliminate pathogen spillover to other species. At this workshop I presented my PhD research with a focus on the heterogeneities of rodent contact in endemic regions of Lassa fever and the implications this may have for transmission of self-disseminating vaccine in these contexts.

An output of the workshop was the development of a policy forum manuscript.

Developing transmissible vaccines for animal infections: Intrinsically safe designs and a staged transparent development process will be essential

This manuscript discusses the series of commitments and strategies for vaccine development that we believe increase the likelihood that the potential risks of vaccine transmission become outweighted by conservation, animal welfare and zoonosis prevention benefits. The manuscript, published in Science is available from the publishers website here or from the University of Glasgow repository here.

Transmissible vaccines for bats to innoculate colonies against rabies virus. Image obtained from https://transmissiblevaccines.org/